Brainstem hemorrhage
Brainstem hemorrhage, is a intracranial hemorrhage in the brainstem.
It may occur in pons, pontomedullary junction, pontomesencephalic junction, midbrain, and medulla. Most of the hematomas in brainstem originate from the branches of the basilar artery supplying the pons. Midbrain and medulla oblongata are practically less common sites of origin of brainstem hemorrhage
Results are consistent with the fact that the hypertensive brainstem hemorrhage predominantly occur in the pons and primary bleedings in the other parts of the brainstem are rare 1).
Classification
Etiology
see Traumatic brainstem hemorrhage
see Brainstem cavernous malformation.
Polster et al. reported 2 post-Chiari decompression surgery brainstem hemorrhage cases with 2-yr follow-up.
Two cases were reviewed in which patients underwent uncomplicated suboccipital craniectomy with expansive autologous pericranium duraplasty for Chiari decompression. Postoperatively, both patients awoke with hemibody sensory and motor deficits. Immediate postoperative magnetic resonance imaging revealed a small hemorrhage within the dorsal medulla in both cases. Follow-up imaging shows resolution along with near complete clinical recovery of deficits.
These cases demonstrated a rare postdecompression surgery-related complication in Chiari malformation. We hypothesize that these hemorrhages may occur from the rapid drainage of cerebrospinal fluid resulting in a loss of positive pressure, allowing a low-pressure hemorrhage to occur. Given that these hemorrhages are of low pressure, recovery is excellent 2).
Hydrogel-coated coils may cause a marked inflammatory response that may result in intracerebral hemorrhage 3).
Secondary to evacuation of chronic subdural hematoma 4).
A case report of a unusual complication of dengue fever 5).
Lumbar drainage ? 6).
After decompressive craniectomy 7).
During transvenous embolization of a cavernous dural arteriovenous fistula 8).
After neural therapy 9).
After surgical removal of arachnoid cyst of the Sylvian fissure 10).
Clinical features
Primary brainstem hemorrhage (PBH) frequently causes severe disturbances of consciousness, papillary abnormalities, as well as respiratory and motor disturbances.
Holmes tremor secondary to brainstem hemorrhage 11).
Shiokawa Y, Saito I, Segawa H, Sano K. [Clinical analysis of brainstem hemorrhage; review]. Nihon Rinsho. 1993 Dec;51 Suppl:199-205. Review. Japanese. PubMed PMID: 8120985.
Shiokawa Y, Yazaki H, Tamura A, Saito I. [Clinical analysis of brainstem hemorrhage; review]. Nihon Rinsho. 2006 Nov 28;64 Suppl 8:442-8. Review. Japanese. PubMed PMID: 17469592.
Diagnosis
Before the advent of computerized tomography (CT), the diagnosis of brainstem hemorrhage was usually made based on the clinical picture or by autopsy.
15 patients were examined with a 0.5-T MR scanner with inversion-recovery (IR) and T2-weighted spin-echo (SE) images. In the acute stage (up to the sixth day), hematomas were hypo- or isointense on IR images and isointense and then hypointense on SE images. In the subacute stages (the seventh day to 2 months), hematomas changed from hypo- or isointensity to hyperintensity centripetally on IR images and to hyperintensity on SE images. Parenchymal reactions were hypointense first on SE images and then on IR images. In the chronic stage (over 2 months), hematomas “disappeared” and the parenchyma was hypointense on both IR and SE images. The superior clinical efficacy of MR imaging relative to CT for the detection of hemorrhage was obvious except in the acute stage, when hematomas had an intensity similar to that of the adjacent brainstem, and the patients usually were in serious condition 12).
Treatment
Outcome
The prognosis has been reported to be highly dependent on the clinical severity at presentation and the presence of certain radiological markers. However, the number of PBH patients enrolled in previous reports tended to be small, and precise statistical analyses were also lacking.
Takeuchi et al. retrospectively reviewed 212 consecutive patients with PBH and analyzed the impact of the clinical or radiological parameters on the outcome of patients with PBH.
Of the 212 patients, 134 (63.2%) were male and 78 (36.8%) were female, with an age range of 17-97 years (mean, 60.3 years). The median admission GCS score was 4. The outcomes included a good recovery in 13 patients (6.1%), moderate disability in 27 (12.7%), severe disability in 27 (12.7%), a vegetative state in 23 (10.8%), and death in 122 (57.5%). A multivariate analysis demonstrated bilateral hematoma extension, a GCS score ≤8, the presence of hydrocephalus, gender, and the hematoma volume to all be significantly associated with the 3-month mortality, while the GCS score ≤8, the presence of a pupillary abnormality, and the hematoma volume were found to be associated with the 3-month poor outcome.
The identification of these factors is therefore considered to be useful for managing patients with PBH 13).
Neutrophil-to-lymphocyte ratio (NLR) , platelet-to-lymphocyte ratio (PLR), and admission blood glucose level (ABG), can be used to independently predict 90-day functional outcome in patients after PBH. When combined, they have better predictive power in identifying PBH patients with a poor prognosis. This study is the first to reveal the associations between NLR, PLR, and hyperglycemia and the functional outcomes of patient with PBH. In associating with previously studies on hemorrhage site, the results provide a good opportunity to elucidate the underlying mechanisms of PBH 14).